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This volume explores sleep medicine, sleep science, and the sleep disorders that keep one-quarter of the U.S. population from getting this necessary component of normal cognitive functioning and survival. With an emphasis on diagnostic techniques, particularly imaging, this handbook shines newfound attention on the genetic and clinical aspects of sleep medicine. Advances in basic science are explored, including a better understanding of sleep-wakefulness and new models of rapid eye movement (REM) sleep mechanisms. Advancements in the understanding of sleep-wake-dependent genes, gene products, and the role of sleep duration in mortality and morbidity are also presented, along with fascinating noninvasive neuroimaging studies that demonstrate marked changes in function during different sleep states. Clinicians will gain new insights into the diagnosis of sleep
disorders and sleep science. In addition, researchers will have an
invaluable tool that will form a foundation for new approaches into
the ongoing study of sleep medicine.
Since the late 90 s, a renewed interest in the neurobiology of sleep has provided new advancements in the understanding of basic sleep science and the clinical aspects of sleep disorders, with particular interest given to the role of genetics. From laboratory techniques and therapies, groundbreaking research in sleep-wakefulness, new models of rapid eye movement (REM) sleep mechanisms, to bright light therapy for circadian rhythm sleep disorders, this handbook will provide clinicians and researchers with a state-of-the-art reference that summarizes the clinical features and management of the many neurological manifestations of sleep disorders. Practitioners will find invaluable research, information, and
laboratory techniques on such topics as sleep-wake-dependent genes,
the role of sleep duration in mortality and morbidity, and
advancements in the understanding of the neurobiology of sleep
disorders, including narcolepsy-cataplexy, restless legs syndrome,
REM behavior disorders, fatal familiar insomnia, sleep apnea and
heart failure, and nocturnal paroxysmal dystonia, amongst others.
In addition, significant advancements in therapies and drug
protocols are presented.
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